toll-like receptor 1
Symbol
Organism
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Tlr1 | Mus musculus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2208 | toll-like receptor 1 increases with age | Molecular | hippocampus | Human | TLR1 | 87.3% Increase Gene Expression Level | |
| DAA2222 | toll-like receptor 1 increases with age | Molecular | parietal lobe | Human | TLR1 | 39.8% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | biological_process | |
| GO:0002282 | microglial cell activation involved in immune response | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0006955 | immune response | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0032493 | response to bacterial lipoprotein | biological_process | |
| GO:0042116 | macrophage activation | biological_process | |
| GO:0042495 | detection of triacyl bacterial lipopeptide | biological_process | |
| GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | biological_process | |
| GO:0042742 | defense response to bacterium | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0045410 | positive regulation of interleukin-6 biosynthetic process | biological_process | |
| GO:0052033 | pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response | biological_process | |
| GO:0071727 | cellular response to triacyl bacterial lipopeptide | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0030670 | phagocytic vesicle membrane | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex | cellular_component | |
| GO:0004872 | receptor activity | molecular_function | |
| GO:0004888 | transmembrane signaling receptor activity | molecular_function | |
| GO:0046982 | protein heterodimerization activity | molecular_function | |
| GO:0071723 | lipopeptide binding | molecular_function | |