transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Symbol

TAP1 (may also be known as: None)

Organism

Human

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Orthologs

SymbolSpecies
tap1 Danio rerio
Tap1 Mus musculus
Tap1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3421 Gene expression of TAP1 increases with age Molecular skin Human TAP1 —

GO Terms

GO IDGO TermGO Category
GO:0001916 positive regulation of T cell mediated cytotoxicity biological_process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent biological_process
GO:0006952 defense response biological_process
GO:0015031 protein transport biological_process
GO:0015833 peptide transport biological_process
GO:0019060 intracellular transport of viral proteins in host cell biological_process
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I biological_process
GO:0042270 protection from natural killer cell mediated cytotoxicity biological_process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0046967 cytosol to ER transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0005739 mitochondrion cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0030670 phagocytic vesicle membrane cellular_component
GO:0042825 TAP complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005215 transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0015197 peptide transporter activity molecular_function
GO:0015421 oligopeptide-transporting ATPase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0042288 MHC class I protein binding molecular_function
GO:0042605 peptide antigen binding molecular_function
GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043531 ADP binding molecular_function
GO:0046978 TAP1 binding molecular_function
GO:0046979 TAP2 binding molecular_function
GO:0046980 tapasin binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function