The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]


sst1.1 Danio rerio
Sst Mus musculus
Sst Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006972 hyperosmotic response biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007267 cell-cell signaling biological_process
GO:0007268 synaptic transmission biological_process
GO:0007584 response to nutrient biological_process
GO:0007586 digestion biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008628 induction of apoptosis by hormones biological_process
GO:0009408 response to heat biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0030334 regulation of cell migration biological_process
GO:0042493 response to drug biological_process
GO:0043200 response to amino acid stimulus biological_process
GO:0048545 response to steroid hormone stimulus biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0005179 hormone activity molecular_function