somatostatin
Symbol
SST
Organism
Human
Description
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| sst1.1 | Danio rerio | |
| Sst | Mus musculus | |
| Sst | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006972 | hyperosmotic response | biological_process | |
| GO:0007166 | cell surface receptor linked signaling pathway | biological_process | |
| GO:0007186 | G-protein coupled receptor signaling pathway | biological_process | |
| GO:0007267 | cell-cell signaling | biological_process | |
| GO:0007268 | synaptic transmission | biological_process | |
| GO:0007584 | response to nutrient | biological_process | |
| GO:0007586 | digestion | biological_process | |
| GO:0008285 | negative regulation of cell proliferation | biological_process | |
| GO:0008628 | induction of apoptosis by hormones | biological_process | |
| GO:0009408 | response to heat | biological_process | |
| GO:0010243 | response to organic nitrogen | biological_process | |
| GO:0030334 | regulation of cell migration | biological_process | |
| GO:0042493 | response to drug | biological_process | |
| GO:0043200 | response to amino acid stimulus | biological_process | |
| GO:0048545 | response to steroid hormone stimulus | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0043025 | neuronal cell body | cellular_component | |
| GO:0005179 | hormone activity | molecular_function | |