secretory leukocyte peptidase inhibitor

Symbol

SLPI (may also be known as: None)

Organism

Human

Description

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Slpi Mus musculus
Slpil2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2426 secretory leukocyte peptidase inhibitor precursor decreases with age Molecular dermis Human SLPI 18.6% Decrease DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0010951 negative regulation of endopeptidase activity biological_process
GO:0032091 negative regulation of protein binding biological_process
GO:0045071 negative regulation of viral genome replication biological_process
GO:0005576 extracellular region cellular_component
GO:0031012 extracellular matrix cellular_component
GO:0004866 endopeptidase inhibitor activity molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0019899 enzyme binding molecular_function