bone morphogenetic protein 6
Symbol
BMP6
(may also be known as: None)
Organism
Human
Description
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Bmp6 | Mus musculus | |
| Bmp6 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2784 | Gene expression of BMP6 increases with age | Molecular | adipose tissue | Human | BMP6 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001501 | skeletal system development | biological_process | |
| GO:0001649 | osteoblast differentiation | biological_process | |
| GO:0001654 | eye development | biological_process | |
| GO:0001822 | kidney development | biological_process | |
| GO:0001938 | positive regulation of endothelial cell proliferation | biological_process | |
| GO:0001958 | endochondral ossification | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0006955 | immune response | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | biological_process | |
| GO:0030501 | positive regulation of bone mineralization | biological_process | |
| GO:0030509 | BMP signaling pathway | biological_process | |
| GO:0030539 | male genitalia development | biological_process | |
| GO:0032349 | positive regulation of aldosterone biosynthetic process | biological_process | |
| GO:0040007 | growth | biological_process | |
| GO:0045603 | positive regulation of endothelial cell differentiation | biological_process | |
| GO:0045666 | positive regulation of neuron differentiation | biological_process | |
| GO:0045669 | positive regulation of osteoblast differentiation | biological_process | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_process | |
| GO:0051216 | cartilage development | biological_process | |
| GO:0060395 | SMAD protein signal transduction | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005125 | cytokine activity | molecular_function | |
| GO:0008083 | growth factor activity | molecular_function | |
| GO:0046982 | protein heterodimerization activity | molecular_function | |
| GO:0070700 | BMP receptor binding | molecular_function | |