serine/arginine-rich splicing factor 2
Symbol
Organism
Description
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| srsf2a | Danio rerio | |
| Srsf2 | Mus musculus | |
| Srsf2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000398 | nuclear mRNA splicing, via spliceosome | biological_process | |
| GO:0006366 | transcription from RNA polymerase II promoter | biological_process | |
| GO:0006369 | termination of RNA polymerase II transcription | biological_process | |
| GO:0006397 | mRNA processing | biological_process | |
| GO:0006406 | mRNA export from nucleus | biological_process | |
| GO:0008380 | RNA splicing | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0031124 | mRNA 3'-end processing | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0016605 | PML body | cellular_component | |
| GO:0016607 | nuclear speck | cellular_component | |
| GO:0000166 | nucleotide binding | molecular_function | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0003714 | transcription corepressor activity | molecular_function | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |