BH3 interacting domain death agonist

Symbol

BID (may also be known as: None)

Organism

Human

Description

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Bid Mus musculus
Bid Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3011 Gene expression of BID decreases with age Molecular skin Human BID —

GO Terms

GO IDGO TermGO Category
GO:0001836 release of cytochrome c from mitochondria biological_process
GO:0006626 protein targeting to mitochondrion biological_process
GO:0006915 apoptotic process biological_process
GO:0007420 brain development biological_process
GO:0008625 induction of apoptosis via death domain receptors biological_process
GO:0008629 induction of apoptosis by intracellular signals biological_process
GO:0008633 activation of pro-apoptotic gene products biological_process
GO:0008637 apoptotic mitochondrial changes biological_process
GO:0032355 response to estradiol stimulus biological_process
GO:0032461 positive regulation of protein oligomerization biological_process
GO:0032464 positive regulation of protein homooligomerization biological_process
GO:0034349 glial cell apoptosis biological_process
GO:0042127 regulation of cell proliferation biological_process
GO:0046902 regulation of mitochondrial membrane permeability biological_process
GO:0051402 neuron apoptosis biological_process
GO:0090150 establishment of protein localization in membrane biological_process
GO:0090200 positive regulation of release of cytochrome c from mitochondria biological_process
GO:2000045 regulation of G1/S transition of mitotic cell cycle biological_process
GO:0005624 membrane fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005741 mitochondrial outer membrane cellular_component
GO:0005829 cytosol cellular_component
GO:0016020 membrane cellular_component
GO:0032592 integral to mitochondrial membrane cellular_component
GO:0005123 death receptor binding molecular_function
GO:0005515 protein binding molecular_function
GO:0031625 ubiquitin protein ligase binding molecular_function