chemokine (C-C motif) ligand 2

Symbol

CCL2 (may also be known as: None)

Organism

Human

Description

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3383 Gene expression of CCL2 increases with age Molecular skin Human CCL2 —

GO Terms

GO IDGO TermGO Category
GO:0000165 MAPKKK cascade biological_process
GO:0001525 angiogenesis biological_process
GO:0001666 response to hypoxia biological_process
GO:0001938 positive regulation of endothelial cell proliferation biological_process
GO:0002548 monocyte chemotaxis biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006874 cellular calcium ion homeostasis biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006935 chemotaxis biological_process
GO:0006954 inflammatory response biological_process
GO:0006959 humoral immune response biological_process
GO:0006987 activation of signaling protein activity involved in unfolded protein response biological_process
GO:0007010 cytoskeleton organization biological_process
GO:0007155 cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger biological_process
GO:0007259 JAK-STAT cascade biological_process
GO:0007568 aging biological_process
GO:0008360 regulation of cell shape biological_process
GO:0009408 response to heat biological_process
GO:0009612 response to mechanical stimulus biological_process
GO:0009617 response to bacterium biological_process
GO:0009887 organ morphogenesis biological_process
GO:0010332 response to gamma radiation biological_process
GO:0010574 regulation of vascular endothelial growth factor production biological_process
GO:0010759 positive regulation of macrophage chemotaxis biological_process
GO:0014823 response to activity biological_process
GO:0016525 negative regulation of angiogenesis biological_process
GO:0019079 viral genome replication biological_process
GO:0019221 cytokine-mediated signaling pathway biological_process
GO:0019725 cellular homeostasis biological_process
GO:0030593 neutrophil chemotaxis biological_process
GO:0030968 endoplasmic reticulum unfolded protein response biological_process
GO:0031100 organ regeneration biological_process
GO:0031663 lipopolysaccharide-mediated signaling pathway biological_process
GO:0032570 response to progesterone stimulus biological_process
GO:0033552 response to vitamin B3 biological_process
GO:0035684 helper T cell extravasation biological_process
GO:0042493 response to drug biological_process
GO:0043200 response to amino acid stimulus biological_process
GO:0043277 apoptotic cell clearance biological_process
GO:0043491 protein kinase B signaling cascade biological_process
GO:0043615 astrocyte cell migration biological_process
GO:0044344 cellular response to fibroblast growth factor stimulus biological_process
GO:0045471 response to ethanol biological_process
GO:0046677 response to antibiotic biological_process
GO:0048010 vascular endothelial growth factor receptor signaling pathway biological_process
GO:0048246 macrophage chemotaxis biological_process
GO:0048247 lymphocyte chemotaxis biological_process
GO:0050806 positive regulation of synaptic transmission biological_process
GO:0050870 positive regulation of T cell activation biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process biological_process
GO:0060137 maternal process involved in parturition biological_process
GO:0070098 chemokine-mediated signaling pathway biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071346 cellular response to interferon-gamma biological_process
GO:0071347 cellular response to interleukin-1 biological_process
GO:0071356 cellular response to tumor necrosis factor biological_process
GO:0071407 cellular response to organic cyclic compound biological_process
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages biological_process
GO:2000502 negative regulation of natural killer cell chemotaxis biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0001664 G-protein coupled receptor binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0008009 chemokine activity molecular_function
GO:0008201 heparin binding molecular_function
GO:0031727 CCR2 chemokine receptor binding molecular_function