ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

Symbol

RAC2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Orthologs

SymbolSpecies
rac-2 Caenorhabditis elegans
Rac2 Drosophila melanogaster
rac2 Danio rerio
Rac2 Mus musculus
Rac2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3355 Gene expression of RAC2 decreases with age Molecular skin Human RAC2 —

GO Terms

GO IDGO TermGO Category
GO:0006184 GTP catabolic process biological_process
GO:0006935 chemotaxis biological_process
GO:0007165 signal transduction biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0007596 blood coagulation biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0010310 regulation of hydrogen peroxide metabolic process biological_process
GO:0030031 cell projection assembly biological_process
GO:0030036 actin cytoskeleton organization biological_process
GO:0030168 platelet activation biological_process
GO:0045453 bone resorption biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0060263 regulation of respiratory burst biological_process
GO:0005622 intracellular cellular_component
GO:0005624 membrane fraction cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003924 GTPase activity molecular_function
GO:0005525 GTP binding molecular_function