poliovirus receptor-related 2 (herpesvirus entry mediator B)

Symbol

PVRL2 (may also be known as: None)

Organism

Human

Description

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Pvrl2 Mus musculus
Pvrl2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3353 Gene expression of PVRL2 decreases with age Molecular skin Human PVRL2 —

GO Terms

GO IDGO TermGO Category
GO:0001675 acrosome assembly biological_process
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target biological_process
GO:0002891 positive regulation of immunoglobulin mediated immune response biological_process
GO:0007010 cytoskeleton organization biological_process
GO:0007155 cell adhesion biological_process
GO:0007156 homophilic cell adhesion biological_process
GO:0007286 spermatid development biological_process
GO:0007289 spermatid nucleus differentiation biological_process
GO:0009566 fertilization biological_process
GO:0019064 viral envelope fusion with host membrane biological_process
GO:0030382 sperm mitochondrion organization biological_process
GO:0032990 cell part morphogenesis biological_process
GO:0033005 positive regulation of mast cell activation biological_process
GO:0034329 cell junction assembly biological_process
GO:0034332 adherens junction organization biological_process
GO:0042271 susceptibility to natural killer cell mediated cytotoxicity biological_process
GO:0043064 flagellum organization biological_process
GO:0044419 interspecies interaction between organisms biological_process
GO:0045216 cell-cell junction organization biological_process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity biological_process
GO:0046814 virion attachment, binding of host cell surface coreceptor biological_process
GO:0050776 regulation of immune response biological_process
GO:0051654 establishment of mitochondrion localization biological_process
GO:0051856 adhesion to symbiont biological_process
GO:0060370 susceptibility to T cell mediated cytotoxicity biological_process
GO:0005886 plasma membrane cellular_component
GO:0005911 cell-cell junction cellular_component
GO:0005915 zonula adherens cellular_component
GO:0009986 cell surface cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0015026 coreceptor activity molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0050839 cell adhesion molecule binding molecular_function