mechanistic target of rapamycin (serine/threonine kinase)

Symbol

Mtor (may also be known as: FRAP, flat)

Organism

Mouse

Orthologs

Symbol	Species
let-363	Caenorhabditis elegans
Tor	Drosophila melanogaster
mtor	Danio rerio
MTOR	Homo sapiens
Mtor	Rattus norvegicus
TOR2	Saccharomyces cerevisiae
tor2	Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA1504	mechanistic target of rapamycin (serine/threonine kinase)	Molecular	kidney	Mouse	Mtor	3.0% Decrease Gene Expression Level

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Changes associated with the orthologs of this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA86	mechanistic target of rapamycin (serine/threonine kinase)	Molecular	brain	Human	MTOR	7.0% Decrease Gene Expression Level

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GO Terms

GO ID	GO Term	GO Category
GO:0001934	positive regulation of protein phosphorylation	biological_process
GO:0001938	positive regulation of endothelial cell proliferation	biological_process
GO:0005979	regulation of glycogen biosynthetic process	biological_process
GO:0006109	regulation of carbohydrate metabolic process	biological_process
GO:0006468	protein phosphorylation	biological_process
GO:0007281	germ cell development	biological_process
GO:0008152	metabolic process	biological_process
GO:0010507	negative regulation of autophagy	biological_process
GO:0010592	positive regulation of lamellipodium assembly	biological_process
GO:0016049	cell growth	biological_process
GO:0016242	negative regulation of macroautophagy	biological_process
GO:0016310	phosphorylation	biological_process
GO:0018105	peptidyl-serine phosphorylation	biological_process
GO:0018107	peptidyl-threonine phosphorylation	biological_process
GO:0030030	cell projection organization	biological_process
GO:0030838	positive regulation of actin filament polymerization	biological_process
GO:0031529	ruffle organization	biological_process
GO:0031669	cellular response to nutrient levels	biological_process
GO:0031929	TOR signaling cascade	biological_process
GO:0031998	regulation of fatty acid beta-oxidation	biological_process
GO:0032095	regulation of response to food	biological_process
GO:0032314	regulation of Rac GTPase activity	biological_process
GO:0032868	response to insulin stimulus	biological_process
GO:0032956	regulation of actin cytoskeleton organization	biological_process
GO:0043200	response to amino acid stimulus	biological_process
GO:0043610	regulation of carbohydrate utilization	biological_process
GO:0045727	positive regulation of translation	biological_process
GO:0045792	negative regulation of cell size	biological_process
GO:0045859	regulation of protein kinase activity	biological_process
GO:0045945	positive regulation of transcription from RNA polymerase III promoter	biological_process
GO:0046777	protein autophosphorylation	biological_process
GO:0046889	positive regulation of lipid biosynthetic process	biological_process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological_process
GO:0051496	positive regulation of stress fiber assembly	biological_process
GO:0051534	negative regulation of NFAT protein import into nucleus	biological_process
GO:0051897	positive regulation of protein kinase B signaling cascade	biological_process
GO:0071456	cellular response to hypoxia	biological_process
GO:0005625	soluble fraction	cellular_component
GO:0005634	nucleus	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005739	mitochondrion	cellular_component
GO:0005741	mitochondrial outer membrane	cellular_component
GO:0005764	lysosome	cellular_component
GO:0005783	endoplasmic reticulum	cellular_component
GO:0005794	Golgi apparatus	cellular_component
GO:0005829	cytosol	cellular_component
GO:0012505	endomembrane system	cellular_component
GO:0016020	membrane	cellular_component
GO:0016605	PML body	cellular_component
GO:0030425	dendrite	cellular_component
GO:0031931	TORC1 complex	cellular_component
GO:0031932	TORC2 complex	cellular_component
GO:0043025	neuronal cell body	cellular_component
GO:0070438	mTOR-FKBP12-rapamycin complex	cellular_component
GO:0000166	nucleotide binding	molecular_function
GO:0001030	RNA polymerase III type 1 promoter DNA binding	molecular_function
GO:0001031	RNA polymerase III type 2 promoter DNA binding	molecular_function
GO:0001032	RNA polymerase III type 3 promoter DNA binding	molecular_function
GO:0001156	TFIIIC-class transcription factor binding	molecular_function
GO:0004674	protein serine/threonine kinase activity	molecular_function
GO:0005515	protein binding	molecular_function
GO:0005524	ATP binding	molecular_function
GO:0016301	kinase activity	molecular_function
GO:0016740	transferase activity	molecular_function
GO:0016772	transferase activity, transferring phosphorus-containing groups	molecular_function
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular_function
GO:0019904	protein domain specific binding	molecular_function
GO:0043022	ribosome binding	molecular_function
GO:0051219	phosphoprotein binding	molecular_function
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