mechanistic target of rapamycin (serine/threonine kinase)

Symbol

MTOR (may also be known as: RAFT1, RAP)

Organism

Human

Orthologs

SymbolSpecies
let-363 Caenorhabditis elegans
Tor Drosophila melanogaster
mtor Danio rerio
Mtor Mus musculus
Mtor Rattus norvegicus
TOR2 Saccharomyces cerevisiae
tor2 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA86 mechanistic target of rapamycin (serine/threonine kinase) Molecular brain Human MTOR 7.0% Decrease Gene Expression Level

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1504 mechanistic target of rapamycin (serine/threonine kinase) Molecular kidney Mouse Mtor 3.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0001938 positive regulation of endothelial cell proliferation biological_process
GO:0005979 regulation of glycogen biosynthetic process biological_process
GO:0006109 regulation of carbohydrate metabolic process biological_process
GO:0006468 protein phosphorylation biological_process
GO:0007165 signal transduction biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0007281 germ cell development biological_process
GO:0007584 response to nutrient biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0010507 negative regulation of autophagy biological_process
GO:0010592 positive regulation of lamellipodium assembly biological_process
GO:0016049 cell growth biological_process
GO:0016242 negative regulation of macroautophagy biological_process
GO:0016310 phosphorylation biological_process
GO:0018105 peptidyl-serine phosphorylation biological_process
GO:0018107 peptidyl-threonine phosphorylation biological_process
GO:0030163 protein catabolic process biological_process
GO:0030838 positive regulation of actin filament polymerization biological_process
GO:0031295 T cell costimulation biological_process
GO:0031529 ruffle organization biological_process
GO:0031669 cellular response to nutrient levels biological_process
GO:0031929 TOR signaling cascade biological_process
GO:0031998 regulation of fatty acid beta-oxidation biological_process
GO:0032095 regulation of response to food biological_process
GO:0032314 regulation of Rac GTPase activity biological_process
GO:0032868 response to insulin stimulus biological_process
GO:0032956 regulation of actin cytoskeleton organization biological_process
GO:0040007 growth biological_process
GO:0043200 response to amino acid stimulus biological_process
GO:0043610 regulation of carbohydrate utilization biological_process
GO:0045727 positive regulation of translation biological_process
GO:0045792 negative regulation of cell size biological_process
GO:0045859 regulation of protein kinase activity biological_process
GO:0045945 positive regulation of transcription from RNA polymerase III promoter biological_process
GO:0046777 protein autophosphorylation biological_process
GO:0046889 positive regulation of lipid biosynthetic process biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0048015 phosphatidylinositol-mediated signaling biological_process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation biological_process
GO:0051496 positive regulation of stress fiber assembly biological_process
GO:0051534 negative regulation of NFAT protein import into nucleus biological_process
GO:0051897 positive regulation of protein kinase B signaling cascade biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005741 mitochondrial outer membrane cellular_component
GO:0005764 lysosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005829 cytosol cellular_component
GO:0005942 phosphatidylinositol 3-kinase complex cellular_component
GO:0012505 endomembrane system cellular_component
GO:0016020 membrane cellular_component
GO:0016605 PML body cellular_component
GO:0030425 dendrite cellular_component
GO:0031931 TORC1 complex cellular_component
GO:0031932 TORC2 complex cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0070438 mTOR-FKBP12-rapamycin complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0001030 RNA polymerase III type 1 promoter DNA binding molecular_function
GO:0001031 RNA polymerase III type 2 promoter DNA binding molecular_function
GO:0001032 RNA polymerase III type 3 promoter DNA binding molecular_function
GO:0001156 TFIIIC-class transcription factor binding molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0016773 phosphotransferase activity, alcohol group as acceptor molecular_function
GO:0019904 protein domain specific binding molecular_function
GO:0043022 ribosome binding molecular_function
GO:0051219 phosphoprotein binding molecular_function