platelet derived growth factor C
Symbol
PDGFC
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| LOC560564 | Danio rerio | |
| Pdgfc | Mus musculus | |
| Pdgfc | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | biological_process | |
| GO:0007275 | multicellular organismal development | biological_process | |
| GO:0007417 | central nervous system development | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0009887 | organ morphogenesis | biological_process | |
| GO:0045740 | positive regulation of DNA replication | biological_process | |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | biological_process | |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | biological_process | |
| GO:0048146 | positive regulation of fibroblast proliferation | biological_process | |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | biological_process | |
| GO:0051781 | positive regulation of cell division | biological_process | |
| GO:0071230 | cellular response to amino acid stimulus | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005788 | endoplasmic reticulum lumen | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0005161 | platelet-derived growth factor receptor binding | molecular_function | |
| GO:0008083 | growth factor activity | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0043498 | cell surface binding | molecular_function | |