peroxisome proliferator-activated receptor gamma

Symbol

PPARG (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
pparg Danio rerio
Pparg Mus musculus
Pparg Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3332 Gene expression of PPARG decreases with age Molecular skin Human PPARG —

GO Terms

GO IDGO TermGO Category
GO:0000122 negative regulation of transcription from RNA polymerase II promoter biological_process
GO:0001818 negative regulation of cytokine production biological_process
GO:0001890 placenta development biological_process
GO:0002674 negative regulation of acute inflammatory response biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0007165 signal transduction biological_process
GO:0007507 heart development biological_process
GO:0007584 response to nutrient biological_process
GO:0008217 regulation of blood pressure biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0009409 response to cold biological_process
GO:0010467 gene expression biological_process
GO:0010745 negative regulation of macrophage derived foam cell differentiation biological_process
GO:0010871 negative regulation of receptor biosynthetic process biological_process
GO:0010887 negative regulation of cholesterol storage biological_process
GO:0010891 negative regulation of sequestering of triglyceride biological_process
GO:0015909 long-chain fatty acid transport biological_process
GO:0019216 regulation of lipid metabolic process biological_process
GO:0030224 monocyte differentiation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030522 intracellular receptor mediated signaling pathway biological_process
GO:0030855 epithelial cell differentiation biological_process
GO:0031000 response to caffeine biological_process
GO:0031100 organ regeneration biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0033189 response to vitamin A biological_process
GO:0033993 response to lipid biological_process
GO:0042493 response to drug biological_process
GO:0042593 glucose homeostasis biological_process
GO:0042953 lipoprotein transport biological_process
GO:0043627 response to estrogen stimulus biological_process
GO:0045087 innate immune response biological_process
GO:0045165 cell fate commitment biological_process
GO:0045600 positive regulation of fat cell differentiation biological_process
GO:0045713 low-density lipoprotein particle receptor biosynthetic process biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046321 positive regulation of fatty acid oxidation biological_process
GO:0048469 cell maturation biological_process
GO:0048714 positive regulation of oligodendrocyte differentiation biological_process
GO:0050872 white fat cell differentiation biological_process
GO:0050873 brown fat cell differentiation biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051974 negative regulation of telomerase activity biological_process
GO:0055088 lipid homeostasis biological_process
GO:0055098 response to low-density lipoprotein particle stimulus biological_process
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway biological_process
GO:0060694 regulation of cholesterol transporter activity biological_process
GO:0071285 cellular response to lithium ion biological_process
GO:0071407 cellular response to organic cyclic compound biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0001012 RNA polymerase II regulatory region DNA binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003682 chromatin binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0003707 steroid hormone receptor activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity molecular_function
GO:0004955 prostaglandin receptor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008144 drug binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0019899 enzyme binding molecular_function
GO:0033613 activating transcription factor binding molecular_function
GO:0043565 sequence-specific DNA binding molecular_function
GO:0044212 transcription regulatory region DNA binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0046965 retinoid X receptor binding molecular_function
GO:0050544 arachidonic acid binding molecular_function