procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Symbol
PLOD1
(may also be known as: None)
Organism
Human
Description
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| let-268 | Caenorhabditis elegans | |
| Plod | Drosophila melanogaster | |
| plod1a | Danio rerio | |
| Plod1 | Mus musculus | |
| Plod1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2825 | Gene expression of PLOD1 decreases with age | Molecular | adipose tissue | Human | PLOD1 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001666 | response to hypoxia | biological_process | |
| GO:0006464 | protein modification process | biological_process | |
| GO:0008544 | epidermis development | biological_process | |
| GO:0046947 | hydroxylysine biosynthetic process | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0005581 | collagen | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0030867 | rough endoplasmic reticulum membrane | cellular_component | |
| GO:0005506 | iron ion binding | molecular_function | |
| GO:0008475 | procollagen-lysine 5-dioxygenase activity | molecular_function | |
| GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | molecular_function | |
| GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | molecular_function | |
| GO:0031418 | L-ascorbic acid binding | molecular_function | |
| GO:0042803 | protein homodimerization activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |