ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b


ATP6V0B (may also be known as: None)




This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]


vha-4 Caenorhabditis elegans
VhaPPA1-1 Drosophila melanogaster
atp6v0b Danio rerio
Atp6v0b Mus musculus
vma16 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006811 ion transport biological_process
GO:0006879 cellular iron ion homeostasis biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0015991 ATP hydrolysis coupled proton transport biological_process
GO:0015992 proton transport biological_process
GO:0033572 transferrin transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0005768 endosome cellular_component
GO:0005773 vacuole cellular_component
GO:0005774 vacuolar membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0033179 proton-transporting V-type ATPase, V0 domain cellular_component
GO:0005215 transporter activity molecular_function
GO:0015078 hydrogen ion transmembrane transporter activity molecular_function