ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Symbol

ATP6V0B (may also be known as: None)

Organism

Human

Description

This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Orthologs

SymbolSpecies
vha-4 Caenorhabditis elegans
VhaPPA1-1 Drosophila melanogaster
atp6v0b Danio rerio
Atp6v0b Mus musculus
vma16 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3004 Gene expression of ATP6V0B decreases with age Molecular skin Human ATP6V0B —

GO Terms

GO IDGO TermGO Category
GO:0006811 ion transport biological_process
GO:0006879 cellular iron ion homeostasis biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0015991 ATP hydrolysis coupled proton transport biological_process
GO:0015992 proton transport biological_process
GO:0033572 transferrin transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0005768 endosome cellular_component
GO:0005773 vacuole cellular_component
GO:0005774 vacuolar membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0033179 proton-transporting V-type ATPase, V0 domain cellular_component
GO:0005215 transporter activity molecular_function
GO:0015078 hydrogen ion transmembrane transporter activity molecular_function