ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1


ATP6V1C1 (may also be known as: None)




This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]


Vha44 Drosophila melanogaster
atp6v1c1a Danio rerio
Atp6v1c1 Mus musculus
Atp6v1c1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006200 ATP catabolic process biological_process
GO:0006810 transport biological_process
GO:0006879 cellular iron ion homeostasis biological_process
GO:0008286 insulin receptor signaling pathway biological_process
GO:0015991 ATP hydrolysis coupled proton transport biological_process
GO:0015992 proton transport biological_process
GO:0033572 transferrin transport biological_process
GO:0034220 ion transmembrane transport biological_process
GO:0055085 transmembrane transport biological_process
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016469 proton-transporting two-sector ATPase complex cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0033180 proton-transporting V-type ATPase, V1 domain cellular_component
GO:0045177 apical part of cell cellular_component
GO:0005215 transporter activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism molecular_function
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances molecular_function
GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function