acyl-CoA synthetase long-chain family member 5

Symbol

ACSL5 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
acs-13 Caenorhabditis elegans
acsl5 Danio rerio
Acsl5 Mus musculus
Acsl5 Rattus norvegicus
FAA2 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006631 fatty acid metabolic process biological_process
GO:0007584 response to nutrient biological_process
GO:0009744 response to sucrose stimulus biological_process
GO:0009749 response to glucose stimulus biological_process
GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport biological_process
GO:0010867 positive regulation of triglyceride biosynthetic process biological_process
GO:0015908 fatty acid transport biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0070723 response to cholesterol biological_process
GO:0005739 mitochondrion cellular_component
GO:0005741 mitochondrial outer membrane cellular_component
GO:0005743 mitochondrial inner membrane cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004467 long-chain fatty acid-CoA ligase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016874 ligase activity molecular_function