anaphase promoting complex subunit 5

Symbol

ANAPC5 (may also be known as: None)

Organism

Human

Description

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

Orthologs

SymbolSpecies
gfi-3 Caenorhabditis elegans
ida Drosophila melanogaster
anapc5 Danio rerio
Anapc5 Mus musculus
Anapc5 Rattus norvegicus
apc5 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3864 Gene expression of ANAPC5 increases with age Molecular skin Human ANAPC5 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0000090 mitotic anaphase biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0006511 ubiquitin-dependent protein catabolic process biological_process
GO:0007094 mitotic cell cycle spindle assembly checkpoint biological_process
GO:0016567 protein ubiquitination biological_process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0051301 cell division biological_process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0070979 protein K11-linked ubiquitination biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005680 anaphase-promoting complex cellular_component
GO:0005829 cytosol cellular_component
GO:0004842 ubiquitin-protein ligase activity molecular_function
GO:0005488 binding molecular_function
GO:0019903 protein phosphatase binding molecular_function