toll-like receptor 8
Symbol
TLR8
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| LOC100332583 | Danio rerio | |
| Tlr8 | Mus musculus | |
| Tlr8 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2215 | Toll-like receptor 8 increases with age | Molecular | hippocampus | Human | TLR8 | 39.7% Increase Gene Expression Level |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006954 | inflammatory response | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | biological_process | |
| GO:0009615 | response to virus | biological_process | |
| GO:0016064 | immunoglobulin mediated immune response | biological_process | |
| GO:0045078 | positive regulation of interferon-gamma biosynthetic process | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0045089 | positive regulation of innate immune response | biological_process | |
| GO:0045356 | positive regulation of interferon-alpha biosynthetic process | biological_process | |
| GO:0045359 | positive regulation of interferon-beta biosynthetic process | biological_process | |
| GO:0045416 | positive regulation of interleukin-8 biosynthetic process | biological_process | |
| GO:0051607 | defense response to virus | biological_process | |
| GO:0071260 | cellular response to mechanical stimulus | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0010008 | endosome membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003723 | RNA binding | molecular_function | |
| GO:0003725 | double-stranded RNA binding | molecular_function | |
| GO:0003727 | single-stranded RNA binding | molecular_function | |
| GO:0004872 | receptor activity | molecular_function | |