toll-like receptor 7


TLR7 (may also be known as: None)




The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]


Tlr7 Mus musculus
Tlr7 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2213 toll-like receptor 7 increases with age Molecular hippocampus Human TLR7 94.7% Increase Gene Expression Level
DAA2214 toll-like receptor 7 increases with age Molecular hippocampus Human TLR7 56.5% Increase Gene Expression Level
DAA2229 toll-like receptor 7 increases with age Molecular parietal lobe Human TLR7 38.8% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002282 microglial cell activation involved in immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007252 I-kappaB phosphorylation biological_process
GO:0032722 positive regulation of chemokine production biological_process
GO:0032755 positive regulation of interleukin-6 production biological_process
GO:0032757 positive regulation of interleukin-8 production biological_process
GO:0034154 toll-like receptor 7 signaling pathway biological_process
GO:0042221 response to chemical stimulus biological_process
GO:0042346 positive regulation of NF-kappaB import into nucleus biological_process
GO:0045078 positive regulation of interferon-gamma biosynthetic process biological_process
GO:0045087 innate immune response biological_process
GO:0045356 positive regulation of interferon-alpha biosynthetic process biological_process
GO:0045359 positive regulation of interferon-beta biosynthetic process biological_process
GO:0045416 positive regulation of interleukin-8 biosynthetic process biological_process
GO:0050729 positive regulation of inflammatory response biological_process
GO:0051607 defense response to virus biological_process
GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005764 lysosome cellular_component
GO:0005768 endosome cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0032009 early phagosome cellular_component
GO:0003725 double-stranded RNA binding molecular_function
GO:0003727 single-stranded RNA binding molecular_function
GO:0004872 receptor activity molecular_function
GO:0008144 drug binding molecular_function
GO:0035197 siRNA binding molecular_function