antioxidant 1 copper chaperone


ATOX1 (may also be known as: None)




This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]


cuc-1 Caenorhabditis elegans
Atox1 Drosophila melanogaster
atox1 Danio rerio
Atox1 Mus musculus
Atox1 Rattus norvegicus
ATX1 Saccharomyces cerevisiae
atx1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006811 ion transport biological_process
GO:0006825 copper ion transport biological_process
GO:0006878 cellular copper ion homeostasis biological_process
GO:0006979 response to oxidative stress biological_process
GO:0030001 metal ion transport biological_process
GO:0005829 cytosol cellular_component
GO:0005507 copper ion binding molecular_function
GO:0016530 metallochaperone activity molecular_function
GO:0016531 copper chaperone activity molecular_function
GO:0032767 copper-dependent protein binding molecular_function
GO:0046872 metal ion binding molecular_function