ATP citrate lyase

Symbol

ACLY (may also be known as: None)

Organism

Human

Description

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
acly-2 Caenorhabditis elegans
ATPCL Drosophila melanogaster
aclya Danio rerio
Acly Mus musculus
Acly Rattus norvegicus
SPBC1703.07 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2973 Gene expression of ACLY decreases with age Molecular skin Human ACLY —

GO Terms

GO IDGO TermGO Category
GO:0006101 citrate metabolic process biological_process
GO:0006112 energy reserve metabolic process biological_process
GO:0006200 ATP catabolic process biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0015936 coenzyme A metabolic process biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0031325 positive regulation of cellular metabolic process biological_process
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044262 cellular carbohydrate metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009346 citrate lyase complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003824 catalytic activity molecular_function
GO:0003878 ATP citrate synthase activity molecular_function
GO:0004775 succinate-CoA ligase (ADP-forming) activity molecular_function
GO:0005488 binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0016874 ligase activity molecular_function
GO:0046872 metal ion binding molecular_function