myelin basic protein

Symbol

MBP (may also be known as: None)

Organism

Human

Description

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
mbpa Danio rerio
Mbp Mus musculus
Mbp Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2072 myelin basic protein increases with age Molecular ovary Human MBP 139.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006955 immune response biological_process
GO:0007268 synaptic transmission biological_process
GO:0007417 central nervous system development biological_process
GO:0008366 axon ensheathment biological_process
GO:0009636 response to toxin biological_process
GO:0042552 myelination biological_process
GO:0050771 negative regulation of axonogenesis biological_process
GO:0005886 plasma membrane cellular_component
GO:0033269 internode region of axon cellular_component
GO:0042995 cell projection cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043209 myelin sheath cellular_component
GO:0043218 compact myelin cellular_component
GO:0002020 protease binding molecular_function
GO:0019911 structural constituent of myelin sheath molecular_function