aryl hydrocarbon receptor nuclear translocator-like

Symbol

ARNTL (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Orthologs

SymbolSpecies
arntl1b Danio rerio
Arntl Mus musculus
Arntl Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0007623 circadian rhythm biological_process
GO:0042176 regulation of protein catabolic process biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0005634 nucleus cellular_component
GO:0005667 transcription factor complex cellular_component
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0017162 aryl hydrocarbon receptor binding molecular_function
GO:0051879 Hsp90 protein binding molecular_function