ras homolog family member G

Symbol

RHOG (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

Orthologs

SymbolSpecies
rhogb Danio rerio
Rhog Mus musculus
Rhog Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2995 Gene expression of RHOG decreases with age Molecular skin Human RHOG —

GO Terms

GO IDGO TermGO Category
GO:0006184 GTP catabolic process biological_process
GO:0007264 small GTPase mediated signal transduction biological_process
GO:0007266 Rho protein signal transduction biological_process
GO:0007411 axon guidance biological_process
GO:0007596 blood coagulation biological_process
GO:0008284 positive regulation of cell proliferation biological_process
GO:0016601 Rac protein signal transduction biological_process
GO:0030036 actin cytoskeleton organization biological_process
GO:0030168 platelet activation biological_process
GO:0032863 activation of Rac GTPase activity biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0051056 regulation of small GTPase mediated signal transduction biological_process
GO:0060326 cell chemotaxis biological_process
GO:0090004 positive regulation of establishment of protein localization in plasma membrane biological_process
GO:0005622 intracellular cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003924 GTPase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005525 GTP binding molecular_function