interleukin 11 receptor, alpha

Symbol

IL11RA (may also be known as: None)

Organism

Human

Description

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Orthologs

SymbolSpecies
il11ra Danio rerio
Il11ra2 Mus musculus
Il11ra1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0007165 signal transduction biological_process
GO:0032502 developmental process biological_process
GO:0060322 head development biological_process
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0004896 cytokine receptor activity molecular_function