inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta


IKBKB (may also be known as: None)




The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]


ikbkb Danio rerio
Ikbkb Mus musculus
Ikbkb Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001782 B cell homeostasis biological_process
GO:0002224 toll-like receptor signaling pathway biological_process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0002756 MyD88-independent toll-like receptor signaling pathway biological_process
GO:0003009 skeletal muscle contraction biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006954 inflammatory response biological_process
GO:0007249 I-kappaB kinase/NF-kappaB cascade biological_process
GO:0007252 I-kappaB phosphorylation biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0009615 response to virus biological_process
GO:0009636 response to toxin biological_process
GO:0034130 toll-like receptor 1 signaling pathway biological_process
GO:0034134 toll-like receptor 2 signaling pathway biological_process
GO:0034138 toll-like receptor 3 signaling pathway biological_process
GO:0034142 toll-like receptor 4 signaling pathway biological_process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway biological_process
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological_process
GO:0042493 response to drug biological_process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade biological_process
GO:0045087 innate immune response biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0048011 nerve growth factor receptor signaling pathway biological_process
GO:0050852 T cell receptor signaling pathway biological_process
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway biological_process
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005792 microsome cellular_component
GO:0005829 cytosol cellular_component
GO:0008385 IkappaB kinase complex cellular_component
GO:0009898 internal side of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0035631 CD40 receptor complex cellular_component
GO:0045121 membrane raft cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008384 IkappaB kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function