Fas (TNF receptor superfamily, member 6)






The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]


fas Danio rerio
Fas Mus musculus
Fas Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001666 response to hypoxia biological_process
GO:0002377 immunoglobulin production biological_process
GO:0003014 renal system process biological_process
GO:0006461 protein complex assembly biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006924 activation-induced cell death of T cells biological_process
GO:0006925 inflammatory cell apoptosis biological_process
GO:0006927 transformed cell apoptosis biological_process
GO:0006955 immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007283 spermatogenesis biological_process
GO:0007568 aging biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0008625 induction of apoptosis via death domain receptors biological_process
GO:0008633 activation of pro-apoptotic gene products biological_process
GO:0009636 response to toxin biological_process
GO:0010035 response to inorganic substance biological_process
GO:0010467 gene expression biological_process
GO:0010940 positive regulation of necrotic cell death biological_process
GO:0019724 B cell mediated immunity biological_process
GO:0031104 dendrite regeneration biological_process
GO:0032464 positive regulation of protein homooligomerization biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0042127 regulation of cell proliferation biological_process
GO:0042493 response to drug biological_process
GO:0042698 ovulation cycle biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043434 response to peptide hormone stimulus biological_process
GO:0043627 response to estrogen stimulus biological_process
GO:0045060 negative thymic T cell selection biological_process
GO:0045619 regulation of lymphocyte differentiation biological_process
GO:0045637 regulation of myeloid cell differentiation biological_process
GO:0048536 spleen development biological_process
GO:0050869 negative regulation of B cell activation biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051402 neuron apoptosis biological_process
GO:0070848 response to growth factor stimulus biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0071285 cellular response to lithium ion biological_process
GO:0071455 cellular response to hyperoxia biological_process
GO:0005576 extracellular region cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031264 death-inducing signaling complex cellular_component
GO:0031265 CD95 death-inducing signaling complex cellular_component
GO:0045121 membrane raft cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004888 transmembrane signaling receptor activity molecular_function
GO:0005031 tumor necrosis factor-activated receptor activity molecular_function
GO:0005488 binding molecular_function
GO:0005515 protein binding molecular_function
GO:0019900 kinase binding molecular_function
GO:0042802 identical protein binding molecular_function