insulin-like growth factor binding protein 4
Symbol
IGFBP4
(may also be known as: None)
Organism
Human
Description
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Igfbp4 | Mus musculus | |
| Igfbp4 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001501 | skeletal system development | biological_process | |
| GO:0001558 | regulation of cell growth | biological_process | |
| GO:0006259 | DNA metabolic process | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0007165 | signal transduction | biological_process | |
| GO:0008283 | cell proliferation | biological_process | |
| GO:0010906 | regulation of glucose metabolic process | biological_process | |
| GO:0040008 | regulation of growth | biological_process | |
| GO:0043410 | positive regulation of MAPKKK cascade | biological_process | |
| GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway | biological_process | |
| GO:0044342 | type B pancreatic cell proliferation | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005520 | insulin-like growth factor binding | molecular_function | |