islet cell autoantigen 1, 69kDa
Symbol
ICA1
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| CABZ01078431.1 | Danio rerio | |
| Ica1 | Mus musculus | |
| Ica1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006836 | neurotransmitter transport | biological_process | |
| GO:0043496 | regulation of protein homodimerization activity | biological_process | |
| GO:0000139 | Golgi membrane | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0005795 | Golgi stack | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0030054 | cell junction | cellular_component | |
| GO:0030425 | dendrite | cellular_component | |
| GO:0030658 | transport vesicle membrane | cellular_component | |
| GO:0030667 | secretory granule membrane | cellular_component | |
| GO:0030672 | synaptic vesicle membrane | cellular_component | |
| GO:0031410 | cytoplasmic vesicle | cellular_component | |
| GO:0045202 | synapse | cellular_component | |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
| GO:0003674 | molecular_function | molecular_function | |
| GO:0019904 | protein domain specific binding | molecular_function | |