acyl-CoA dehydrogenase, long chain
Symbol
ACADL
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| acadl | Danio rerio | |
| Acadl | Mus musculus | |
| Acadl | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001659 | temperature homeostasis | biological_process | |
| GO:0006631 | fatty acid metabolic process | biological_process | |
| GO:0006635 | fatty acid beta-oxidation | biological_process | |
| GO:0019254 | carnitine metabolic process, CoA-linked | biological_process | |
| GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | biological_process | |
| GO:0042413 | carnitine catabolic process | biological_process | |
| GO:0042758 | long-chain fatty acid catabolic process | biological_process | |
| GO:0044242 | cellular lipid catabolic process | biological_process | |
| GO:0044255 | cellular lipid metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0045717 | negative regulation of fatty acid biosynthetic process | biological_process | |
| GO:0046322 | negative regulation of fatty acid oxidation | biological_process | |
| GO:0051289 | protein homotetramerization | biological_process | |
| GO:0055114 | oxidation-reduction process | biological_process | |
| GO:0090181 | regulation of cholesterol metabolic process | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005739 | mitochondrion | cellular_component | |
| GO:0005759 | mitochondrial matrix | cellular_component | |
| GO:0031966 | mitochondrial membrane | cellular_component | |
| GO:0000062 | fatty-acyl-CoA binding | molecular_function | |
| GO:0003995 | acyl-CoA dehydrogenase activity | molecular_function | |
| GO:0004466 | long-chain-acyl-CoA dehydrogenase activity | molecular_function | |
| GO:0016401 | palmitoyl-CoA oxidase activity | molecular_function | |
| GO:0050660 | flavin adenine dinucleotide binding | molecular_function | |