apoptotic peptidase activating factor 1


APAF1 (may also be known as: None)




This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]


Ark Drosophila melanogaster
apaf1 Danio rerio
Apaf1 Mus musculus
Apaf1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006915 apoptotic process biological_process
GO:0006919 activation of caspase activity biological_process
GO:0006952 defense response biological_process
GO:0007399 nervous system development biological_process
GO:0008629 induction of apoptosis by intracellular signals biological_process
GO:0008635 activation of caspase activity by cytochrome c biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0097193 intrinsic apoptotic signaling pathway biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005829 cytosol cellular_component
GO:0043293 apoptosome cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process molecular_function
GO:0043531 ADP binding molecular_function