major histocompatibility complex, class II, DR beta 1
Symbol
Organism
Description
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2137 | major histocompatibility complex, class II, DR beta 1 increases with age | Molecular | frontal lobe | Human | HLA-DRB1 | 83.0% Increase Gene Expression Level | |
DAA2370 | major histocompatibility complex, class II, DR beta 1 increases with age | Molecular | frontal lobe | Human | HLA-DRB1 | 84.8% Increase Gene Expression Level | |
DAA2136 | major histocompatibility complex, class II, DR beta 1 increases with age | Molecular | parietal lobe | Human | HLA-DRB1 | 90.3% Increase Gene Expression Level | |
DAA2365 | major histocompatibility complex, class II, DR beta 1 increases with age | Molecular | parietal lobe | Human | HLA-DRB1 | 111.1% Increase Gene Expression Level | |
DAA2135 | major histocompatibility complex, class II, DR beta 1 increases with age | Molecular | hippocampus | Human | HLA-DRB1 | 193.5% Increase Gene Expression Level | |
DAA2360 | major histocompatibility complex, class II, DR beta 1 increases with age | Molecular | hippocampus | Human | HLA-DRB1 | 204.2% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | biological_process | |
GO:0006955 | immune response | biological_process | |
GO:0007165 | signal transduction | biological_process | |
GO:0019221 | cytokine-mediated signaling pathway | biological_process | |
GO:0031295 | T cell costimulation | biological_process | |
GO:0032673 | regulation of interleukin-4 production | biological_process | |
GO:0050852 | T cell receptor signaling pathway | biological_process | |
GO:0051262 | protein tetramerization | biological_process | |
GO:0060333 | interferon-gamma-mediated signaling pathway | biological_process | |
GO:2001179 | regulation of interleukin-10 secretion | biological_process | |
GO:0005765 | lysosomal membrane | cellular_component | |
GO:0005768 | endosome | cellular_component | |
GO:0005783 | endoplasmic reticulum | cellular_component | |
GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
GO:0005794 | Golgi apparatus | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0005887 | integral to plasma membrane | cellular_component | |
GO:0009897 | external side of plasma membrane | cellular_component | |
GO:0016020 | membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0031902 | late endosome membrane | cellular_component | |
GO:0042613 | MHC class II protein complex | cellular_component | |
GO:0032395 | MHC class II receptor activity | molecular_function | |
GO:0042605 | peptide antigen binding | molecular_function | |