hook microtubule-tethering protein 2


HOOK2 (may also be known as: None)




Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]


zyg-12 Caenorhabditis elegans
hk Drosophila melanogaster
Hook2 Mus musculus
Hook2 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000226 microtubule cytoskeleton organization biological_process
GO:0006897 endocytosis biological_process
GO:0007032 endosome organization biological_process
GO:0007040 lysosome organization biological_process
GO:0008333 endosome to lysosome transport biological_process
GO:0015031 protein transport biological_process
GO:0045022 early endosome to late endosome transport biological_process
GO:0005737 cytoplasm cellular_component
GO:0005813 centrosome cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005874 microtubule cellular_component
GO:0030897 HOPS complex cellular_component
GO:0070695 FHF complex cellular_component
GO:0005515 protein binding molecular_function
GO:0008017 microtubule binding molecular_function
GO:0042802 identical protein binding molecular_function