STEAP family member 2, metalloreductase

Symbol

STEAP2 (may also be known as: None)

Organism

Human

Description

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
steap2 Danio rerio
Steap2 Mus musculus
Steap2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4412 Gene expression of STEAP2 increases with age Molecular skin Human STEAP2 —

GO Terms

GO IDGO TermGO Category
GO:0006811 ion transport biological_process
GO:0006893 Golgi to plasma membrane transport biological_process
GO:0006897 endocytosis biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0022900 electron transport chain biological_process
GO:0045055 regulated secretory pathway biological_process
GO:0055072 iron ion homeostasis biological_process
GO:0005769 early endosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0010008 endosome membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030140 trans-Golgi network transport vesicle cellular_component
GO:0030173 integral to Golgi membrane cellular_component
GO:0042598 vesicular fraction cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005215 transporter activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0009055 electron carrier activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050660 flavin adenine dinucleotide binding molecular_function