arachidonate 15-lipoxygenase, type B


ALOX15B (may also be known as: None)




This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]


si:dkey-17e16.9 Danio rerio
Alox15b Mus musculus
Alox15b Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006629 lipid metabolic process biological_process
GO:0006631 fatty acid metabolic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0019370 leukotriene biosynthetic process biological_process
GO:0030336 negative regulation of cell migration biological_process
GO:0030850 prostate gland development biological_process
GO:0030856 regulation of epithelial cell differentiation biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0045926 negative regulation of growth biological_process
GO:0005622 intracellular cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005506 iron ion binding molecular_function
GO:0016165 lipoxygenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0050473 arachidonate 15-lipoxygenase activity molecular_function