arachidonate 5-lipoxygenase-activating protein


ALOX5AP (may also be known as: None)




This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]


alox5ap Danio rerio
Alox5ap Mus musculus
Alox5ap Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0002540 leukotriene production involved in inflammatory response biological_process
GO:0019370 leukotriene biosynthetic process biological_process
GO:0070207 protein homotrimerization biological_process
GO:0071277 cellular response to calcium ion biological_process
GO:0005634 nucleus cellular_component
GO:0005635 nuclear envelope cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0004051 arachidonate 5-lipoxygenase activity molecular_function
GO:0004464 leukotriene-C4 synthase activity molecular_function
GO:0004602 glutathione peroxidase activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008047 enzyme activator activity molecular_function
GO:0019899 enzyme binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0047485 protein N-terminus binding molecular_function
GO:0050544 arachidonic acid binding molecular_function