fructose-1,6-bisphosphatase 1


FBP1 (may also be known as: None)




Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]


fbp1b Danio rerio
Fbp1 Mus musculus
Fbp1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006000 fructose metabolic process biological_process
GO:0006002 fructose 6-phosphate metabolic process biological_process
GO:0006006 glucose metabolic process biological_process
GO:0006094 gluconeogenesis biological_process
GO:0006111 regulation of gluconeogenesis biological_process
GO:0016311 dephosphorylation biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0032869 cellular response to insulin stimulus biological_process
GO:0035690 cellular response to drug biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045820 negative regulation of glycolysis biological_process
GO:0046580 negative regulation of Ras protein signal transduction biological_process
GO:0051289 protein homotetramerization biological_process
GO:0071286 cellular response to magnesium ion biological_process
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005515 protein binding molecular_function
GO:0016208 AMP binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity molecular_function
GO:0042578 phosphoric ester hydrolase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0048029 monosaccharide binding molecular_function