fructose-1,6-bisphosphatase 1

Symbol

FBP1 (may also be known as: None)

Organism

Human

Description

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

Orthologs

Symbol	Species
fbp1b	Danio rerio
Fbp1	Mus musculus
Fbp1	Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3132	Gene expression of FBP1 decreases with age	Molecular	skin	Human	FBP1	—

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GO Terms

GO ID	GO Term	GO Category
GO:0005975	carbohydrate metabolic process	biological_process
GO:0006000	fructose metabolic process	biological_process
GO:0006002	fructose 6-phosphate metabolic process	biological_process
GO:0006006	glucose metabolic process	biological_process
GO:0006094	gluconeogenesis	biological_process
GO:0006111	regulation of gluconeogenesis	biological_process
GO:0016311	dephosphorylation	biological_process
GO:0030308	negative regulation of cell growth	biological_process
GO:0032869	cellular response to insulin stimulus	biological_process
GO:0035690	cellular response to drug	biological_process
GO:0044281	small molecule metabolic process	biological_process
GO:0045820	negative regulation of glycolysis	biological_process
GO:0046580	negative regulation of Ras protein signal transduction	biological_process
GO:0051289	protein homotetramerization	biological_process
GO:0071286	cellular response to magnesium ion	biological_process
GO:0005625	soluble fraction	cellular_component
GO:0005737	cytoplasm	cellular_component
GO:0005829	cytosol	cellular_component
GO:0005515	protein binding	molecular_function
GO:0016208	AMP binding	molecular_function
GO:0016787	hydrolase activity	molecular_function
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	molecular_function
GO:0042578	phosphoric ester hydrolase activity	molecular_function
GO:0046872	metal ion binding	molecular_function
GO:0048029	monosaccharide binding	molecular_function
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