allograft inflammatory factor 1


AIF1 (may also be known as: None)




This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]


Aif1 Mus musculus
Aif1 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001934 positive regulation of protein phosphorylation biological_process
GO:0006950 response to stress biological_process
GO:0006954 inflammatory response biological_process
GO:0007050 cell cycle arrest biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0010629 negative regulation of gene expression biological_process
GO:0014739 positive regulation of muscle hyperplasia biological_process
GO:0030335 positive regulation of cell migration biological_process
GO:0031668 cellular response to extracellular stimulus biological_process
GO:0032870 cellular response to hormone stimulus biological_process
GO:0034097 response to cytokine stimulus biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0048661 positive regulation of smooth muscle cell proliferation biological_process
GO:0048678 response to axon injury biological_process
GO:0051017 actin filament bundle assembly biological_process
GO:0051602 response to electrical stimulus biological_process
GO:0070887 cellular response to chemical stimulus biological_process
GO:0001726 ruffle cellular_component
GO:0001891 phagocytic cup cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0005856 cytoskeleton cellular_component
GO:0005884 actin filament cellular_component
GO:0005886 plasma membrane cellular_component
GO:0030027 lamellipodium cellular_component
GO:0032587 ruffle membrane cellular_component
GO:0043204 perikaryon cellular_component
GO:0005509 calcium ion binding molecular_function
GO:0051015 actin filament binding molecular_function