acyl-CoA wax alcohol acyltransferase 1
Symbol
AWAT1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| Awat1 | Mus musculus | |
| Awat1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0008610 | lipid biosynthetic process | biological_process | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0016747 | transferase activity, transferring acyl groups other than amino-acyl groups | molecular_function | |
| GO:0047196 | long-chain-alcohol O-fatty-acyltransferase activity | molecular_function | |