cathepsin K

Symbol

CTSK (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

Orthologs

SymbolSpecies
ctsk Danio rerio
Ctsk Mus musculus
Ctsk Rattus norvegicus

Links to external resources

Changes associated with this gene

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1290 cathepsin K Molecular visual apparatus Mouse Ctsk 58.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0001957 intramembranous ossification biological_process
GO:0006508 proteolysis biological_process
GO:0045453 bone resorption biological_process
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005764 lysosome cellular_component
GO:0004197 cysteine-type endopeptidase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008234 cysteine-type peptidase activity molecular_function