interleukin 34
Symbol
IL34
(may also be known as: None)
Organism
Human
Description
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| si:ch211-239j19.3 | Danio rerio | |
| Il34 | Mus musculus | |
| Il34 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2458 | hypothetical protein LOC146433 decreases with age | Molecular | mesenchymal stem cell | Human | IL34 | 27.7% Decrease DNA Methylation | |
| DAA2409 | interleukin 34 decreases with age | Molecular | dermis | Human | IL34 | 17.6% Decrease DNA Methylation |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0001934 | positive regulation of protein phosphorylation | biological_process | |
| GO:0006954 | inflammatory response | biological_process | |
| GO:0008284 | positive regulation of cell proliferation | biological_process | |
| GO:0045087 | innate immune response | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0005125 | cytokine activity | molecular_function | |
| GO:0005157 | macrophage colony-stimulating factor receptor binding | molecular_function | |
| GO:0008083 | growth factor activity | molecular_function | |