glutamate-cysteine ligase, catalytic subunit

Symbol

Gclc (may also be known as: Glclc, GLC)

Organism

Mouse

Orthologs

SymbolSpecies
gcs-1 Caenorhabditis elegans
Gclc Drosophila melanogaster
gclc Danio rerio
GCLC Homo sapiens
Gclc Rattus norvegicus
GSH1 Saccharomyces cerevisiae
gcs1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1972 Glutamate-cysteine ligase (GCL) Km decrease Molecular liver Mouse Gclc —

GO Terms

GO IDGO TermGO Category
GO:0006534 cysteine metabolic process biological_process
GO:0006536 glutamate metabolic process biological_process
GO:0006749 glutathione metabolic process biological_process
GO:0006750 glutathione biosynthetic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0006979 response to oxidative stress biological_process
GO:0008152 metabolic process biological_process
GO:0009408 response to heat biological_process
GO:0009410 response to xenobiotic stimulus biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0019852 L-ascorbic acid metabolic process biological_process
GO:0031397 negative regulation of protein ubiquitination biological_process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0043524 negative regulation of neuron apoptosis biological_process
GO:0045454 cell redox homeostasis biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0046685 response to arsenic-containing substance biological_process
GO:0050880 regulation of blood vessel size biological_process
GO:0051409 response to nitrosative stress biological_process
GO:0051900 regulation of mitochondrial depolarization biological_process
GO:0005829 cytosol cellular_component
GO:0017109 glutamate-cysteine ligase complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0000287 magnesium ion binding molecular_function
GO:0004357 glutamate-cysteine ligase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016595 glutamate binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0043531 ADP binding molecular_function
GO:0046982 protein heterodimerization activity molecular_function
GO:0050662 coenzyme binding molecular_function