poly (ADP-ribose) polymerase 1
Symbol
PARP1
Organism
Human
Description
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| pme-1 | Caenorhabditis elegans | |
| Parp | Drosophila melanogaster | |
| parp1 | Danio rerio | |
| Parp1 | Mus musculus | |
| Parp1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000723 | telomere maintenance | biological_process | |
| GO:0006281 | DNA repair | biological_process | |
| GO:0006284 | base-excision repair | biological_process | |
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006366 | transcription from RNA polymerase II promoter | biological_process | |
| GO:0006471 | protein ADP-ribosylation | biological_process | |
| GO:0016540 | protein autoprocessing | biological_process | |
| GO:0032869 | cellular response to insulin stimulus | biological_process | |
| GO:0040009 | regulation of growth rate | biological_process | |
| GO:0042769 | DNA damage response, detection of DNA damage | biological_process | |
| GO:0070212 | protein poly-ADP-ribosylation | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005635 | nuclear envelope | cellular_component | |
| GO:0005654 | nucleoplasm | cellular_component | |
| GO:0005667 | transcription factor complex | cellular_component | |
| GO:0005730 | nucleolus | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0008134 | transcription factor binding | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0016757 | transferase activity, transferring glycosyl groups | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |
| GO:0047485 | protein N-terminus binding | molecular_function | |
| GO:0051287 | NAD binding | molecular_function | |