cyclin-dependent kinase inhibitor 2A


Cdkn2a (may also be known as: Arf, p16, )




Cdkn2a Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000209 protein polyubiquitination biological_process
GO:0001953 negative regulation of cell-matrix adhesion biological_process
GO:0006309 DNA fragmentation involved in apoptotic nuclear change biological_process
GO:0006351 transcription, DNA-dependent biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006364 rRNA processing biological_process
GO:0006469 negative regulation of protein kinase activity biological_process
GO:0006915 apoptotic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0007049 cell cycle biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007568 aging biological_process
GO:0007569 cell aging biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008544 epidermis development biological_process
GO:0008637 apoptotic mitochondrial changes biological_process
GO:0009303 rRNA transcription biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0010389 regulation of G2/M transition of mitotic cell cycle biological_process
GO:0010468 regulation of gene expression biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030889 negative regulation of B cell proliferation biological_process
GO:0031647 regulation of protein stability biological_process
GO:0031648 protein destabilization biological_process
GO:0032088 negative regulation of NF-kappaB transcription factor activity biological_process
GO:0033088 negative regulation of immature T cell proliferation in thymus biological_process
GO:0033235 positive regulation of protein sumoylation biological_process
GO:0033600 negative regulation of mammary gland epithelial cell proliferation biological_process
GO:0034393 positive regulation of smooth muscle cell apoptosis biological_process
GO:0035019 somatic stem cell maintenance biological_process
GO:0035986 senescence-associated heterochromatin focus assembly biological_process
GO:0042326 negative regulation of phosphorylation biological_process
GO:0042493 response to drug biological_process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator biological_process
GO:0045736 negative regulation of cyclin-dependent protein kinase activity biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046822 regulation of nucleocytoplasmic transport biological_process
GO:0046825 regulation of protein export from nucleus biological_process
GO:0048103 somatic stem cell division biological_process
GO:0050821 protein stabilization biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051444 negative regulation of ubiquitin-protein ligase activity biological_process
GO:0060058 positive regulation of apoptosis involved in mammary gland involution biological_process
GO:0070534 protein K63-linked ubiquitination biological_process
GO:0071158 positive regulation of cell cycle arrest biological_process
GO:0090398 cellular senescence biological_process
GO:0090399 replicative senescence biological_process
GO:2000111 positive regulation of macrophage apoptosis biological_process
GO:2000774 positive regulation of cellular senescence biological_process
GO:0001652 granular component cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0035985 senescence-associated heterochromatin focus cellular_component
GO:0043234 protein complex cellular_component
GO:0002039 p53 binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0004861 cyclin-dependent protein kinase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0051059 NF-kappaB binding molecular_function
GO:0055105 ubiquitin-protein ligase inhibitor activity molecular_function
GO:0070215 MDM2 binding molecular_function