cyclin-dependent kinase inhibitor 2A

Symbol

Cdkn2a (may also be known as: Arf, p16, )

Organism

Mouse

Orthologs

SymbolSpecies
Cdkn2a Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1977 p16 expression increases Molecular whole body Mouse Cdkn2a —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000079 regulation of cyclin-dependent protein kinase activity biological_process
GO:0000082 G1/S transition of mitotic cell cycle biological_process
GO:0000209 protein polyubiquitination biological_process
GO:0001953 negative regulation of cell-matrix adhesion biological_process
GO:0006309 DNA fragmentation involved in apoptotic nuclear change biological_process
GO:0006351 transcription, DNA-dependent biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0006364 rRNA processing biological_process
GO:0006469 negative regulation of protein kinase activity biological_process
GO:0006915 apoptotic process biological_process
GO:0006917 induction of apoptosis biological_process
GO:0006919 activation of caspase activity biological_process
GO:0007049 cell cycle biological_process
GO:0007050 cell cycle arrest biological_process
GO:0007568 aging biological_process
GO:0007569 cell aging biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008544 epidermis development biological_process
GO:0008637 apoptotic mitochondrial changes biological_process
GO:0009303 rRNA transcription biological_process
GO:0010243 response to organic nitrogen biological_process
GO:0010389 regulation of G2/M transition of mitotic cell cycle biological_process
GO:0010468 regulation of gene expression biological_process
GO:0014070 response to organic cyclic compound biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0030889 negative regulation of B cell proliferation biological_process
GO:0031647 regulation of protein stability biological_process
GO:0031648 protein destabilization biological_process
GO:0032088 negative regulation of NF-kappaB transcription factor activity biological_process
GO:0033088 negative regulation of immature T cell proliferation in thymus biological_process
GO:0033235 positive regulation of protein sumoylation biological_process
GO:0033600 negative regulation of mammary gland epithelial cell proliferation biological_process
GO:0034393 positive regulation of smooth muscle cell apoptosis biological_process
GO:0035019 somatic stem cell maintenance biological_process
GO:0035986 senescence-associated heterochromatin focus assembly biological_process
GO:0042326 negative regulation of phosphorylation biological_process
GO:0042493 response to drug biological_process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator biological_process
GO:0045736 negative regulation of cyclin-dependent protein kinase activity biological_process
GO:0045786 negative regulation of cell cycle biological_process
GO:0045892 negative regulation of transcription, DNA-dependent biological_process
GO:0045893 positive regulation of transcription, DNA-dependent biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter biological_process
GO:0046822 regulation of nucleocytoplasmic transport biological_process
GO:0046825 regulation of protein export from nucleus biological_process
GO:0048103 somatic stem cell division biological_process
GO:0050821 protein stabilization biological_process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity biological_process
GO:0051444 negative regulation of ubiquitin-protein ligase activity biological_process
GO:0060058 positive regulation of apoptosis involved in mammary gland involution biological_process
GO:0070534 protein K63-linked ubiquitination biological_process
GO:0071158 positive regulation of cell cycle arrest biological_process
GO:0090398 cellular senescence biological_process
GO:0090399 replicative senescence biological_process
GO:2000111 positive regulation of macrophage apoptosis biological_process
GO:2000774 positive regulation of cellular senescence biological_process
GO:0001652 granular component cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0035985 senescence-associated heterochromatin focus cellular_component
GO:0043234 protein complex cellular_component
GO:0002039 p53 binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 sequence-specific DNA binding transcription factor activity molecular_function
GO:0004861 cyclin-dependent protein kinase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0008134 transcription factor binding molecular_function
GO:0019901 protein kinase binding molecular_function
GO:0051059 NF-kappaB binding molecular_function
GO:0055105 ubiquitin-protein ligase inhibitor activity molecular_function
GO:0070215 MDM2 binding molecular_function