serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3


SERPINA3 (may also be known as: None)




The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]


Serpina3b Mus musculus
uncharacterized_F1LV Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006953 acute-phase response biological_process
GO:0006954 inflammatory response biological_process
GO:0010951 negative regulation of endopeptidase activity biological_process
GO:0019216 regulation of lipid metabolic process biological_process
GO:0030162 regulation of proteolysis biological_process
GO:0030277 maintenance of gastrointestinal epithelium biological_process
GO:0005576 extracellular region cellular_component
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0003677 DNA binding molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity molecular_function
GO:0005515 protein binding molecular_function
GO:0030414 peptidase inhibitor activity molecular_function